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The start-up hit the headlines last year after securing high-profile hires from established operators.
Zamboglou was appointed CEO in October 2024, coming from a role as UK and Ireland managing director at evoke. He previously held senior roles at William Hill and Entain.
Zamboglou announced his resignation on social media earlier this week, stating he is stepping down “with immediate effect”.
Speaking to NEXT.io, Zamboglou revealed plans to launch a new venture, Oneiro Labs, which will also focus on Web3 betting and gaming.
The business is set to launch in June and will be headquartered in Gibraltar.
“Since joining the Web3 world, I have seen the huge opportunity and want to be able to realise my own ambitions and vision within this sector,” he said.
He also confirmed that the rest of Blockasset’s C-suite is also preparing to leave and plans to join him in the new business.
“Yes, it’s fair to say the C-suite team will join me, but at this point I can’t give names,” he said.
Zamboglou was introduced last year as the first of several senior hires aimed at expanding Blockasset’s presence in the GambleFi sector.
Among the hires were CMO Michael Sheehan, former director of marketing UK at evoke and ex-strategy marketing director at William Hill, as well as CPTO Michael Wallington, who joined in March from Gibraltar-based Patrianna after holding product leadership roles at DAZN Bet and William Hill.
Blockasset has not issued a formal statement regarding the leadership exits. However, NEXT.iounderstands that co-founder Paul Evans is stepping in as the new CEO.
NEXT.iohas reached out for comment.
Originally launched in 2021 as an athlete NFT and tokenisation platform, Blockasset has expanded into a crypto sports and betting ecosystem.
The company made a significant move into GambleFi with the launch of BlockBet in July 2024.
Shortly after his CEO appointment, Zamboglou said: “One of the big things that we want to bring to crypto gambling is reputation, transparency and openness, and being really honest, we know that’s lacking in the industry at the moment.
“We want to be open and honest with our regulator, and we want to bring trust to a sector that desperately needs it.”